Philosophy
4 min read
December 10, 2022
Human symbiosis of health

Human symbiosis of health

The body is an intelligent, interconnected system where every function depends on another. Health, performance, and resilience are only as strong as the weakest link—neglect one system, and the entire structure begins to fail.

You are only as ‘strong’ as your weakest link

Our body is a complex yet beautiful organism that we barely scrape the surface when it comes to an understanding of how we work.

What we do know is that every system within our body is interdependent on one another. It works and flows synergistically and has a bidirectional relationship.

We often prioritise aesthetics whilst neglecting other systems, only paying attention to them when it is too late and hardship, dysfunction, or disease has manifested as a consequence.

The following systems are what need respect, nurture, and care:

  • Muscular System
  • Structural
  • Endocrinological
  • Neurological
  • Gastro-Intestinal
  • Microbial
  • Cardiovascular System
  • Pulmonary System
  • Immunological
  • Biotransformation
  • Lymphatic System
  • Psychological
  • Emotional
  • Environmental
  • Spiritual

Next news

The effectiveness of Vitamin B6 in the treatment of PMS dates back over 40 years. Results were noted, such as:

  • ‘Significant decreases in all symptoms’ (1)
  • 70% reporting good or partial response’ (2)
  • ‘Improvement in 63% of patients on pyridoxine’ (3)

The dose used within these studies ranged from 40-200mg (with a possible risk of toxicity at 200mg).

Only one patient of the 940 participating in these trials indicated the presence of any side effects that could be attributed to the neuropathy associated with pyridoxine toxicity. (4)

A meta-analysis of nine published trials involving almost 1,000 women with PMS found that vitamin B6 is more effective in reducing PMS symptoms than placebo. (5)

A double-blind, randomized controlled trial in 94 women found that 80 mg pyridoxine taken daily over the course of three cycles was associated with statistically significant reductions in a broad range of PMS symptoms, including:

  • Moodiness
  • Irritability
  • Forgetfulness
  • Bloating
  • Anxiety (6)

Below are my preferred dietary sources of Vitamin B6 per 100g:

  • Liver – 1mg
  • Salmon – 0.9mg
  • Sunflower Seeds – 1.33mg
  • Pistachios – 1.7mg

The recommended daily allowance sits around 1.3mg, which makes an easy target to obtain via food.

However, to achieve the dosage used in the above studies is between 30-153 times higher than the RDA, making it unachievable to obtain through diet alone.

As you can see here, Designs For Health provides 50mg of Vitamin B6 in just one capsule. This is in the form of Vitamin B6 in its most bioavailable form – P5P.

Magnesium and Vitamin B2 are required for the conversion of P5P. The deficiency rates of magnesium make this conversion much harder.

High protein diets or genetic susceptibilities (such as NBPF3) are factors that can increase the need for more Vitamin B6.

Have you ever used B6 for your PMS?

References:

  1. Goei and Abraham, 1983
  2. Brush, 1988
  3. Day, 1979
  4. London RS, et al. 1991
  5. Wyatt KM, et al. BMJ 1999
  6. Kashanian M, et al. 2007
Nutrition
6 min read
Vitamin B6 and PMS
Vitamin B6 and PMS
While food sources can meet daily requirements, the doses shown to improve PMS are difficult to reach through diet alone. Supplemental B6, particularly in its bioactive form (P5P), alongside adequate magnesium and vitamin B2, may support symptom reduction in susceptible individuals.
December 10, 2022

Depression is a complex disease with multiple contributing factors. The diagnostic criteria for depression include:

  • Depressed or irritable mood
  • Decreased interest in pleasurable activities and ability to experience pleasure
  • Significant weight gain or loss (>5% change in a month)
  • Insomnia or hypersomnia
  • Psychomotor agitation or retardation
  • Fatigue or loss of energy
  • Feelings of worthlessness or excessive guilt
  • Diminished ability to think or concentrate
  • Recurrent thoughts of death or suicide
    (Berton O, et al. Nat Rev Neurosci. 2006)

Chances are that you have felt several of the above criteria but yet you may not have associated it with depression.

This is because depression is a broad term that may affect one person differently to the next, along with having a diverse range of possible causations.

Below is a list of some of the factors that can lead to depression and apathy:

  • Trauma
  • PTSD
  • Abuse
  • Post-natal depression
  • Adverse childhood exposure
  • Lack of safety
  • Economic struggles
  • Autoimmunity
  • Social isolation
  • Heartbreak
  • Social media
  • Lack of purpose
  • S.A.D – Seasonal Affective Disorder (Vitamin D deficiency)
  • Mold exposure
  • Anaemia
  • Sex hormone imbalances (Low/high oestrogen, low testosterone)
  • Hypo/hyper thyroidism
  • Stress
  • Pain
  • Chronic illness
  • Genetic traits
  • Methylation issues
  • Heavy metal toxicity
  • Parasites
  • Nutrient deficiencies (B6, etc)
  • Nutrient excess
  • Artificial light exposure
  • Poor sleep
  • Mitochondrial dysfunctions
  • Poor gut health
  • Gut/brain axis inflammation
  • Cytokine model of depression
  • Medication
  • Loss of a loved one
  • Divorce
  • Substance abuse
  • Neurotransmitter imbalances
  • Lyme
  • Toxic and ambivalent relationships

Each reason, being so unique, may require a completely different approach for therapy from the next.

This reverberates a quote of William Osler, stating ‘It is much more important to know what sort of a patient has a disease than what sort of a disease a patient has’. Unfortunately, society generally neglects the beauty of individuality whilst overlooking the crucial interplay and synergy from the multifactorial systems essential for optimal function within our body.

Mental Health
6 min read
The diversity of depression
The diversity of depression
Depression can arise from trauma, physiology, lifestyle, environment, or biochemical imbalance. Because no two cases are the same, effective care depends on understanding the individual—not just the diagnosis.
December 10, 2022

The myth of quitting

Vaping is often promoted as a tool to help people stop smoking, yet the data tells a different story. Although 85% of e-cigarette users report starting vaping to quit cigarettes, a 2013 study across four countries published in the American Journal of Preventive Medicine found they were no more likely to quit than those who never vaped. In fact, reports show that vaping often reduces the likelihood of quitting altogether, with around 70% of users becoming dual users—continuing to smoke while vaping.

What’s actually in the vapour

A 2017 Harvard study analysing 24 flavoured e-cigarette brands found that every single one contained at least one aldehyde or flavouring chemical listed as “High Priority” by FEMA or classified by the FDA as Harmful or Potentially Harmful. Despite this, these products are inhaled repeatedly every day.

We also don’t fully understand how common ingredients—propylene glycol, vegetable glycerin, flavourings, and other additives—behave when heated and aerosolised, especially when used 20 to 30 times a day beyond their original FDA approval context.

Lung injury and toxic exposure

The risks became highly visible during the 2019 outbreak of vaping-associated lung injuries, which resulted in 2,807 hospitalisations and 68 deaths in under a year. One major contributing factor was vitamin E acetate—an additive whose harmless-sounding name masked its severe effects when inhaled.

Research from Johns Hopkins examining 56 e-cigarette devices found that many produced aerosols containing potentially unsafe levels of lead, chromium, manganese, and nickel. These metals originate from heated metal coils and are linked to lung, liver, immune, cardiovascular, and neurological damage, as well as certain cancers. The danger is amplified by ethyl maltol, a common artificial sweetener shown to facilitate the transport of heavy metals into cells.

Cardiovascular and clotting risks

Vaping also exposes users to high concentrations of ultra-fine particles and toxins at levels comparable to conventional cigarettes. These particles activate platelets, increasing their tendency to clump together—an important contributor to clot formation and cardiovascular disease.

Research from Poland suggests that chemicals such as acrolein and formaldehyde, created during e-liquid heating, accelerate arterial hardening and narrowing by more than 1.6 times. Studies from the University of California, San Francisco found that daily e-cigarette use doubles the risk of heart attack, while dual users face a fivefold increase compared to non-smokers.

Hormones, fertility, and pregnancy

The effects extend beyond the lungs and heart. A 2022 study found that vaping doubles the risk of erectile dysfunction in men aged 20 and over. A separate 2020 study of 1,221 men showed a 34% reduction in total sperm count among e-cigarette users compared to non-users.

E-cigarettes contain endocrine-disrupting compounds capable of interfering with hormonal balance and reproductive function. In women, a large study involving 71,940 participants found that unfavourable birth outcomes increased by 62% among those who used e-cigarettes during pregnancy.

Immune suppression and hidden contaminants

Vaping weakens the body’s ability to fight infections. A 2018 study published in BMJ Thorax showed that e-cigarette vapour damages alveolar macrophages—key immune cells responsible for clearing pathogens, toxins, and allergens from the lungs.

Additional concerns come from contamination: an analysis of the ten top-selling U.S. brands detected endotoxins above the limit of detection in 23% of samples tested, adding another layer of inflammatory risk.

Beyond health: society and the environment

Beyond physiology, there is a broader cost. The argument that vaping benefits society is weak when considering its environmental impact. Each disposable vape contains a lithium-ion battery; in the UK alone, the lithium discarded annually in vapes could produce around 1,200 electric vehicle batteries.

On a social level, vaping increasingly functions as an emotional crutch—an “adult pacifier” that outsources stress regulation and potentially disrupts brain chemistry and hormonal balance rather than addressing underlying causes.

The real experiment

E-cigarette use continues to grow rapidly, while robust long-term research on its health effects remains limited. What we do know already points to serious risks—many of which mirror or compound those of smoking itself.

Don’t be society’s guinea pig. It’s time to confront the dark side of vaping.

Detox
6 min read
The dark side of vaping
The dark side of vaping
Despite widespread belief, vaping does not reliably help people quit smoking and frequently leads to dual use. Studies link e-cigarettes to lung injury, heavy metal exposure, hormonal disruption, fertility issues, cardiovascular disease, and impaired immune function. With limited long-term research, rising usage, and significant environmental costs, vaping represents a large-scale experiment on public health—one with increasingly alarming warning signs.
May 6, 2023
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