Detox
4 min read
November 14, 2022
The lymphatic system

The lymphatic system

The lymphatic system is a vital yet often overlooked network responsible for waste removal, immune defence, fluid balance, and systemic homeostasis. Functioning as the body’s internal drainage and filtration system, it supports nearly every other physiological process—from immunity and detoxification to inflammation control, organ health, and brain function.

What is the Lymphatic System?

The lymphatic system is becoming increasingly more talked about but is still, in my opinion, one of the least appreciated and under-utilised systems in the restoration of movement dysfunctions and chronic health complaints.

Everybody, including health practitioners and those in the fitness industry, could benefit from understanding and implementing lymphatic techniques. You can consider that a homeostatic balance of the internal environment can be a true measure of health.

Lymphatic techniques can, therefore, aid the body in moving towards more of an internal state of homeostasis.

How does the lymphatic system function?

The lymphatic system is, in essence, the sewage system of the body.

It has the incredible ability to trap nearly all soluble antigens, roughly 99%, with its role in waste removal. This is significantly important for the other body systems to not become overwhelmed and develop issues as well.

The lymphatic system contains the thymus, an endocrine organ which is responsible for the development of T-lymphocytes, immune cells that are involved in fighting infection through the process of cell-mediated immunity.

The spleen plays a key role in the lymphatic system as the largest lymphatic organ, having a vital role in a host of detox processes, such as:

  • Filtering blood
  • Removing old dead red blood cells
  • The maturation of lymphocytes and macrophages to aid in fighting infection

The splenic communication of the tenth cranial nerve, the Vagus nerve, is crucial in reducing inflammatory cytokine production.

The tonsils also form part of the structure of the lymphatic system. With the tonsils formed of lymphatic tissue, housing lymphocytes and macrophages, they protect the digestive system and lungs from pathogens entering through the nose or mouth.

There is also a deep association with the gastrointestinal system through gut associated lymphoid tissues (GALT) known as Peyers Patches, with the role of the gastrointestinal system intrinsically linked to the immune system. Estimates suggest that roughly 70-80% of immune function is beholden to gastrointestinal health.

This amazing system also comprises millions of lymphatic vessels which, if placed end to end in a continuous line, would circle the earth four times! Alongside these vessels there are over seven hundred lymph nodes within the body, with the most populated areas being the neck, skin and the intestines.

This mass of lymphatic vessels works in uniform direction towards the heart, with valves interspersed to prevent any backflow from occurring. This one-way system is aided by the structure of the vessels which allow fluids to flow in the direction of clearance, but with numerous valves preventing backflow. Allowing the system to be cleared, very much how a filtration device on a fish tank would work.

The ability to regulate fluid homeostasis is a key aspect of the lymphatic system. The body contains fifteen litres of lymphatic fluid, predominantly of water, and roughly 10% of proteins, hormones and waste products. Comparing this to the five litres of circulating blood that we have, the body wouldn’t contain three times more lymphatic fluid than blood if it wasn’t a critical component of our survival!

From the five litres of circulating blood, over the course of a day, three litres of plasma leaks out into the interstitial space.

If not appropriately removed through the lymphatic system this can lead to swelling outside of the cellular space due to the increased fluid concentration and alterations in pressure.

Without effective drainage this can create stagnation in the fluids;
Let’s go back to the fish tank analogy above, we know that stagnation of fluids is detrimental to the ecosystem, the same being the case for our health.

In a system with appropriately functioning lymphatics, this plasma is removed from the interstitial space into the lymphatics system and circulated upwards towards the subclavian vein. This is where it flows into the venous system, before returning to the liver, detoxifying and purifying the blood.

Taking a deeper look into the pathway of the lymphatic vessels will give an understanding into the application of treating the lymphatic system.

As a one way system drains into the venous system at the bilateral sites of the subclavian veins, all lymphatic vessels are required to flow in this direction. The right upper quadrant of the body drains through the right lymphatic duct and into the right subclavian vein, whilst the remainder of the body drains through the thoracic duct into the left subclavian vein.

The thoracic duct is responsible for the majority of lymphatic flow and also houses the largest lymph node, the cisterna chyli, which is a major site of drainage for the liver. It’s crucial to keep this node functioning well as between 25-50% of the returning lymphatic fluid through the thoracic duct is returned from the liver.

There is an important bidirectional relationship between the cisterna chyli and the liver, with an overburdened liver that can’t move or function optimally placing more load on the cisterna chyli. Having a lymphatic system that can’t drain well, especially at the cisterna chyli, increases the potential to create stagnation around the liver. A lymphatic vessel that is unable to drain will not be able to receive fresh supply creating this backlog.

A fairly recent discovery reveals that the lymphatic system also continues up into the central nervous system through the glymphatics, more commonly known as the glymphatic system.

The glymphatic system has the same role as the lymphatic system, however it is only situated in the brain. This helps to reduce inflammation and drive the removal of waste products which is essential for overall brain health. Additionally, the protective benefits of this system helps to distribute fuel sources and various other vital components around the brain.

Next news

Have you suffered challenges to your mental health?

Depression has the third highest burden of all diseases in Australia (13%) [1] and also third globally [2].

Almost half (45%) Australians will experience a mental illness in their lifetime [3].

One in five, about 20%, Australians aged 16-85 experience a mental illness in any year:

  • 11.5% have one disorder and 8.5% have two or more disorders.
  • 14% of Australians suffer from anxiety disorders.
  • 6% depressive disorders [4].

The age with the highest prevalence of mental illness is between 18-24 years of age.

21.2% of adolescents between 15-19 years of age met the criteria for a probable serious mental illness [5].

Six Australians die from suicide every single day, with a further 30 people will attempt to take their own life [6].

Suicide is the leading cause of death for people Australians aged 25-44 and the second leading cause of death for young people aged 15-24 [7].

Australians are more likely to die by suicide than skin cancer.

Indigenous Australians experience double the rate of suicide when compared to non-indigenous Australians [8].

The LGBT community experiences four times the rate when compared with those identified as heterosexual [9].

In 2011, men accounted for 76% of deaths from suicide [10], yet an estimated 72% of males don’t seek help for mental disorders.

54% of sufferers with mental illness do not seek treatment [1], which is only compounded by the delay in treatment due to problems with detection, social stigma and accurate diagnosis.

Individuals with mental illness accessing treatment are half that of people seeking treatment with physical disorders [11].It’s time to raise awareness for mental health.

References

  1. Australian Institute of Health and Welfare. (2014). Australia’s Health 2014. AIHW: Canberra.
  2. World Health Organisation. (2008). The global burden of disease: 2004 update.
  3. Australian Bureau of Statistics. (2009). National Survey of Mental Health and Wellbeing: Summary of Results, 4326.0, 2007. ABS: Canberra.
  4. Kitchener, B.A. and Jorm, A.F. (2009). Youth Mental Health First Aid: A manual for adults assisting youth. ORYGEN Research Centre, Melbourne.
  5. Ivancic, L., Perrens, B., Fildes, J., Perry, Y. and Christensen, H. (2014). Youth Mental Health Report, June 2014. Mission Australia and Black Dog Institute, Sydney.
  6. The Australian Senate. (2010). The Hidden Toll: Suicide in Australia Report of the Senate Community Affairs References Committee. Commonwealth of Australia, Canberra.
  7. http://www.aihw.gov.au/deaths/causes-of- death
  8. Australian Bureau of Statistic. (2012). Australian Health Survey: First Results. ABS, Canberra.
  9. National Mental Health Commission. (2013). A Contributing Life, the 2013 National Report Card on Mental Health and Suicide Prevention. NMHC, Sydney.
  10. Department of Health and Ageing. (2013). National Mental Health Report 2013: tracking progress of mental health reform in Australia 1993 – 2011. Commonwealth of Australia, Canberra.
  11. Commonwealth of Australia. (2010). National Mental Health Report 2010. Canberra, Australia.
Mental Health
6 min read
Mental health: do you care?
Mental health: do you care?
Mental health conditions are common, serious, and often untreated. Reducing stigma, improving early intervention, and encouraging help-seeking are critical steps toward prevention, support, and saving lives.
December 10, 2022

The paradigm of depression being a disease/disorder has evolved around the concept that neurotransmitters are primarily the root cause.

Yet, dysregulation in this field could very well be a symptom, coping mechanism and signal from a multitude of different issues ranging from inside, as well as outside of the body (as explained in my previous post).

The association of depression solely being linked to low levels of norepinephrine and serotonin is flawed throughout studies. There are many other variables that can result in this outcome.

Several studies indicate that as few as 25% of depressed patients have low levels of neurotransmitters, while paradoxically, some patients have abnormally high levels of neurotransmitters with no history of them ever being low.

Does the placement of depression into the category of disease/disorder attach a greater overwhelming thought process to the word than if we were to label it as a symptom?

One could argue that generally speaking, symptoms are alleviated with greater ease when compared with the disease.

It is easy to allow our identity to be taken hostage by adopting the ownership of depression and succumb to its depths.

Yet when we shift our thinking to understand that depression does not embody us as individuals, nor does it yield an element involved in modeling our identity, we shift our thoughts to a greater sense of self-empowerment.

We can overcome the ‘depression vs self’ mentality by accepting that depression is an adaptive and protective mechanism from the human body, accompanied with respect for the opportunity it brings forth to gain further insight into what needs nurturing.

I understand this is a challenging and delicate shift to take, yet the perception of the experience is paramount to one’s thoughts.

Could we disempower the shackling chains of emotional paralysis, gain buoyancy in the swamp of thoughts and restore vitality into one’s behaviour when depression is approached in the light of a symptom?

Can we utilise it as foresight with direction to what may require attention and care within our body and how we live?

This paradigm shift allows more of a harmonious level of awareness with the experience of depression and what possibilities it may bring.

References:

  1. Asberg M, et al. Arch Gen Psychiatry. 1976
  2. Mol Psychiatry. 2010 March
  3. Della FP, et al. Pharmacol Biochem Behav. 2012
  4. Della FP, et al. Behav Brain Res. 2012
  5. Della FP, et al. Metab Brain Dis. 2013

Mental Health
6 min read
Depression: disease or symptom?
Depression: disease or symptom?
Viewing depression as a symptom rather than an identity can foster self-empowerment, insight, and more personalised paths to healing—shifting focus from labels to understanding what the body and mind may be asking for attention and care.
December 10, 2022

The effectiveness of Vitamin B6 in the treatment of PMS dates back over 40 years. Results were noted, such as:

  • ‘Significant decreases in all symptoms’ (1)
  • 70% reporting good or partial response’ (2)
  • ‘Improvement in 63% of patients on pyridoxine’ (3)

The dose used within these studies ranged from 40-200mg (with a possible risk of toxicity at 200mg).

Only one patient of the 940 participating in these trials indicated the presence of any side effects that could be attributed to the neuropathy associated with pyridoxine toxicity. (4)

A meta-analysis of nine published trials involving almost 1,000 women with PMS found that vitamin B6 is more effective in reducing PMS symptoms than placebo. (5)

A double-blind, randomized controlled trial in 94 women found that 80 mg pyridoxine taken daily over the course of three cycles was associated with statistically significant reductions in a broad range of PMS symptoms, including:

  • Moodiness
  • Irritability
  • Forgetfulness
  • Bloating
  • Anxiety (6)

Below are my preferred dietary sources of Vitamin B6 per 100g:

  • Liver – 1mg
  • Salmon – 0.9mg
  • Sunflower Seeds – 1.33mg
  • Pistachios – 1.7mg

The recommended daily allowance sits around 1.3mg, which makes an easy target to obtain via food.

However, to achieve the dosage used in the above studies is between 30-153 times higher than the RDA, making it unachievable to obtain through diet alone.

As you can see here, Designs For Health provides 50mg of Vitamin B6 in just one capsule. This is in the form of Vitamin B6 in its most bioavailable form – P5P.

Magnesium and Vitamin B2 are required for the conversion of P5P. The deficiency rates of magnesium make this conversion much harder.

High protein diets or genetic susceptibilities (such as NBPF3) are factors that can increase the need for more Vitamin B6.

Have you ever used B6 for your PMS?

References:

  1. Goei and Abraham, 1983
  2. Brush, 1988
  3. Day, 1979
  4. London RS, et al. 1991
  5. Wyatt KM, et al. BMJ 1999
  6. Kashanian M, et al. 2007
Nutrition
6 min read
Vitamin B6 and PMS
Vitamin B6 and PMS
While food sources can meet daily requirements, the doses shown to improve PMS are difficult to reach through diet alone. Supplemental B6, particularly in its bioactive form (P5P), alongside adequate magnesium and vitamin B2, may support symptom reduction in susceptible individuals.
December 10, 2022
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