Gut Health
4 min read
December 10, 2022
H Pylori: 50% globally infected

H Pylori: 50% globally infected

Helicobacter pylori is a highly prevalent gram-negative bacterium that colonises the gastrointestinal tract, including the oral cavity. While often asymptomatic, it is a major driver of chronic gastritis, peptic ulcer disease, impaired nutrient absorption, and increased gastric cancer risk, with wide-ranging systemic effects.

Globally, more than 50% of all people are infected [8], with the prevalence of escalating with age. [9]

Helicobacter Pylori is a gram-negative bacterium that colonises within the human gastrointestinal tract (this includes the mouth).

Symptoms:

  • Belching
  • Nausea
  • Vomiting
  • Difficulty swallowing
  • Abdominal discomfort
  • Upper abdominal bloating
  • Decreased appetite
  • Peptic ulcers
  • Bad breath
  • Heartburn
  • Reoccurring oral plaque
  • Gingivitis
  • Tooth cavities

Risks:

  • H. Pylori infection is the main cause of chronic gastritis, with an infection rate between 80%-95% in sufferers. [7]
  • It is present in almost all cases of duodenal ulcers and most cases of gastric ulcer [10] with as many as 90% of individuals with ulcers being infected.
  • H. Pylori is a significant contributing factor for the risk of gastric cancers.
  • H. Pylori burrows deep within parietal cells (cells that secrete stomach acid), not only does this make it harder to eradicate, but this also leads to unique symptoms within the host. One factor being hypochlorhydria (low levels of stomach acid secreted within the body); this prevents the host from sterilising bacteria in food, reduces the ability to obtain nutrients desired from food and the inability to assimilate certain key minerals, such as zinc or iron.
  • Reduced intrinsic factor (IF) production is also likely for individuals suffering from a H. Pylori infection. IF is essential to bind with vitamin B12, preventing further breakdown from stomach acid along with attaching to the surface of the ileum to allow for absorption of B12 into the body.
  • H. Pylori can also block vitamin C absorption, thus compounding to the amount of oxidative damage inflicted onto the body.
  • H. Pylori infection augments the gastric mucosal damage induced by NSAIDs.
  • H. Pylori antagonises Aspirin-induced delayed ulcer healing due to suppression of acid secretion by the enhancement of PGE2 possibly derived by COX2 expression.
  • Benefits:
    Due to the nature of the parasite being a gram-negative bacteria, it shifts the immune system more towards a Th1 mediated response as opposed to Th2 – this can reduce the severity of allergies, asthma and other humeral/mucosal reactions.

Benefits:

Due to the nature of the parasite being a gram-negative bacteria, it shifts the immune system more towards a Th1 mediated response as opposed to Th2 – this can reduce the severity of allergies, asthma and other humeral/mucosal reactions.

References:

  1. Morales-Espinosa R, et al., Oral Microbiol Immunol. 2009
  2. Nguyen AM, et al., Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995
  3. Miyabayashi H, et al., Helicobacter. 2000
  4. Gebara EC, et al., J Clin Periodontol. 2006
  5. Dye BA, et al., Am J Public Health. 2002
  6. Eskandari A, et al. Med Oral Patol Oral Cir Bucal.
  7. Abro AH, et al. J Ayub Med Coll Abbottabad. 2011
  8. Saudi J Gastroenterol. 2014
  9. J Gastrointestin Liver Dis. 2011
  10. J Gastroenterol Hepatol. 2011
  11. Surveillance of Helicobacter pylori antibiotic resistance in England and Wales; Public Health England, 2008
  12. Jernberg, C, et al. 2010

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What is the Lymphatic System?

The lymphatic system is becoming increasingly more talked about but is still, in my opinion, one of the least appreciated and under-utilised systems in the restoration of movement dysfunctions and chronic health complaints.

Everybody, including health practitioners and those in the fitness industry, could benefit from understanding and implementing lymphatic techniques. You can consider that a homeostatic balance of the internal environment can be a true measure of health.

Lymphatic techniques can, therefore, aid the body in moving towards more of an internal state of homeostasis.

How does the lymphatic system function?

The lymphatic system is, in essence, the sewage system of the body.

It has the incredible ability to trap nearly all soluble antigens, roughly 99%, with its role in waste removal. This is significantly important for the other body systems to not become overwhelmed and develop issues as well.

The lymphatic system contains the thymus, an endocrine organ which is responsible for the development of T-lymphocytes, immune cells that are involved in fighting infection through the process of cell-mediated immunity.

The spleen plays a key role in the lymphatic system as the largest lymphatic organ, having a vital role in a host of detox processes, such as:

  • Filtering blood
  • Removing old dead red blood cells
  • The maturation of lymphocytes and macrophages to aid in fighting infection

The splenic communication of the tenth cranial nerve, the Vagus nerve, is crucial in reducing inflammatory cytokine production.

The tonsils also form part of the structure of the lymphatic system. With the tonsils formed of lymphatic tissue, housing lymphocytes and macrophages, they protect the digestive system and lungs from pathogens entering through the nose or mouth.

There is also a deep association with the gastrointestinal system through gut associated lymphoid tissues (GALT) known as Peyers Patches, with the role of the gastrointestinal system intrinsically linked to the immune system. Estimates suggest that roughly 70-80% of immune function is beholden to gastrointestinal health.

This amazing system also comprises millions of lymphatic vessels which, if placed end to end in a continuous line, would circle the earth four times! Alongside these vessels there are over seven hundred lymph nodes within the body, with the most populated areas being the neck, skin and the intestines.

This mass of lymphatic vessels works in uniform direction towards the heart, with valves interspersed to prevent any backflow from occurring. This one-way system is aided by the structure of the vessels which allow fluids to flow in the direction of clearance, but with numerous valves preventing backflow. Allowing the system to be cleared, very much how a filtration device on a fish tank would work.

The ability to regulate fluid homeostasis is a key aspect of the lymphatic system. The body contains fifteen litres of lymphatic fluid, predominantly of water, and roughly 10% of proteins, hormones and waste products. Comparing this to the five litres of circulating blood that we have, the body wouldn’t contain three times more lymphatic fluid than blood if it wasn’t a critical component of our survival!

From the five litres of circulating blood, over the course of a day, three litres of plasma leaks out into the interstitial space.

If not appropriately removed through the lymphatic system this can lead to swelling outside of the cellular space due to the increased fluid concentration and alterations in pressure.

Without effective drainage this can create stagnation in the fluids;
Let’s go back to the fish tank analogy above, we know that stagnation of fluids is detrimental to the ecosystem, the same being the case for our health.

In a system with appropriately functioning lymphatics, this plasma is removed from the interstitial space into the lymphatics system and circulated upwards towards the subclavian vein. This is where it flows into the venous system, before returning to the liver, detoxifying and purifying the blood.

Taking a deeper look into the pathway of the lymphatic vessels will give an understanding into the application of treating the lymphatic system.

As a one way system drains into the venous system at the bilateral sites of the subclavian veins, all lymphatic vessels are required to flow in this direction. The right upper quadrant of the body drains through the right lymphatic duct and into the right subclavian vein, whilst the remainder of the body drains through the thoracic duct into the left subclavian vein.

The thoracic duct is responsible for the majority of lymphatic flow and also houses the largest lymph node, the cisterna chyli, which is a major site of drainage for the liver. It’s crucial to keep this node functioning well as between 25-50% of the returning lymphatic fluid through the thoracic duct is returned from the liver.

There is an important bidirectional relationship between the cisterna chyli and the liver, with an overburdened liver that can’t move or function optimally placing more load on the cisterna chyli. Having a lymphatic system that can’t drain well, especially at the cisterna chyli, increases the potential to create stagnation around the liver. A lymphatic vessel that is unable to drain will not be able to receive fresh supply creating this backlog.

A fairly recent discovery reveals that the lymphatic system also continues up into the central nervous system through the glymphatics, more commonly known as the glymphatic system.

The glymphatic system has the same role as the lymphatic system, however it is only situated in the brain. This helps to reduce inflammation and drive the removal of waste products which is essential for overall brain health. Additionally, the protective benefits of this system helps to distribute fuel sources and various other vital components around the brain.

Detox
6 min read
The lymphatic system
The lymphatic system
By clearing waste, regulating fluid movement, and supporting immune and neurological health, the lymphatic system plays a central role in resilience and recovery. Optimising lymphatic flow can be a powerful, underutilised tool in addressing chronic health issues and restoring balance within the body.
November 14, 2022

Nutrition is the language of our cells –it dictates how we look, feel, function and perform. It is drastically undervalued when compared the uncountable list of benefits proper nutrition can yield. For this reason, I have decided to write about my top choices of foods that support physiological or neurological changes to favour improved training performance. My initial thoughts were to create a ‘top 10 foods’ article but anyone who knows me, will understand that I really love getting into the nitty-gritty detail.

This will be a 5-part series ranging through meats, nuts, seeds all the way through to vegetables and fruits.

Focal Points

The primary focal point for strength performance is to increase neurological drive (supporting dopamine and acetylcholine production) whilst avoiding any suppression (which would be induced from any GABAergic or serotonergic actions). This will optimise drive, motivation, muscle contraction, muscular tone, focus and clarity whilst avoiding any inhabitation or relaxation.

Other key factors to look at when improving performance would be to ensure that there are optimal levels muscle carnosine levels to buffer PH and offset fatigue, support thyroid function, improve blood flow, support DNA formation, strengthening structural connective tissue and activating the correct pathways to supply the body with available energy stores.

For optimum strength performance, you preferably want to avoid carbohydrates pre-training to ensure there is no pump-induced fatigue and to minimise serotonin secretion – therefore fats and proteins are best choices.

This being said, everyone is individual and what will be highly beneficial for one person may not reap similar effects in another due to food intolerances, nutrient status, hormonal levels and genetic code.

Bone broth – do you even bone though?

This is classed as ‘natures multi mineral’. For thousands of years humans have consumed bones, with theories going as far back as Palaeolithic eras. Bone broths contain bio-available minerals (easily absorbed by the body) such as; calcium, magnesium, phosphorus, silicon, sulphur to chondroitin sulphate and glucosamine.

Cooking bones in a broth releases a combination of nutrients that support:

  • Healthy joint mobility and function
  • Collagen biosynthesis
  • Modulating appropriate immune and inflammatory responses
  • Improved gut health
  • Joint health is a key limiting factor on strength and performance. The neurological system will inhibit strength as a self-safety mechanism to protect the joints by preventing any further damage.

One of the most valuable components of bone broth is gelatin, this acts like a soft cushion between bones that helps them move without friction. Gelatin also provides us with building blocks that are needed to form and maintain strong bones; helping take pressure off aging joints and supporting heathy bone mineral density. Weight training can increase bone density, joint health and mobility but only when it is complemented with an appropriate nutrient regime to feed the specific prosperities to do so.

Another key nutrient in bone broth is collagen, this is found in everything from our joints, bones, ligaments and tendons all the way down to the cellular level. Collagen supports the function of chondrocytes, these are small cells found within the cartilage of joints. Chondrocytes produce mucopolysaccharides and the formation of new collagen that keep joints cushioned and lubricated. Research done by the Department of Nutrition and Sports Nutrition for Athletics at Penn State University found that when athletes supplemented with collagen over the course of 24 weeks, there was significant improvements in joint comfort and a decrease in factors that negatively impacted athletic performance. (Clark KL1, Sebastianelli W, Flechsenhar KR, Aukermann DF, Meza F, Millard RL, Deitch JR, Sherbondy PS, Albert A)

Another powerful nutrient that supports joint health and functionality in bone broth is hyaluronic acid; this acts as a “shock absorber” for joints. It holds water and forms a gel-like substance, lubricating and cushioning joints by surrounding tissues found around nerves (predominantly found in the synovial fluid between joints).

Bone broth is also loaded with glycine. This is classed as a ‘conditionally essential’ amino acid. It is used in the synthesis of haemoglobin, creatine, porphyrin, bile salts, glutathione and the nucleotides DNA and RNA. Glycine is involved in gluconeogenesis (the manufacture of glucose), it helps drive glucose into cells acting similar to the function of insulin. ‘When glycine was ingested with glucose, the plasma glucose area response was attenuated by > 50% compared with the response after the ingestion of glucose alone’ (Mary C Gannon, Jennifer A Nuttall, and Frank Q Nuttall). This means that the athlete with be able to have a slighter high carbohydrate intake to restore glycogen levels, support mTOR, mitigate cortisol and improve training performance.

Glycine also assists digestion by enhancing gastric acid secretion. Research found that only certain proteins stimulate gastric acid secretion, glycine being one (Wald A, Adibi SA.) – thus helping protein digestion and assimilation for enhanced recovery from workout to workout.

Bone broths help mediate appropriate immune and inflammatory responses due to the nature of healing the gut wall (due to nutrients such as proline, glutamine, arginine, gelatin and collagen). This will improve the gut walls integrity and prevent intestinal damage and permeability. If the gut wall becomes permeable, undigested food, toxins and pathogens can pass through the intestinal barrier and into the bloodstream, resulting in a hyper-vigilant immune and inflammatory response to address the ‘foreign invaders’. A healthy response is required for appropriate modulation of training-induced inflammation and endocrine function to enable efficient recovery and optimise super-compensation for growth and development.

Last but certainly not least; roughly 66% of neurotransmitter (chemical brain messengers dictating functions throughout the body) production is made within the gut. If there is any distress or down-regulation in the gut, neurotransmitter production will decrease – resulting in a decrease neural drive.

If the gut wall is inflamed, there is high chance that the brains barrier (blood-brain-barrier) will also be inflamed due to inflammatory stimulation from the vagus nerve, a nerve connecting the gut directly to the brain. This will decrease the brains performance and neurotransmitter reception in the brain.

Go hard or go bone.

Learning to love liver

Organs meats are incredibly abundant in B vitamins, these are essential in detoxification, the citric acid cycle (energy production), neurotransmitter conversions amongst many other key functions within the body crucial for training performance and recovery.

Catechol-O-Methyltransferase (COMT) is one of several enzymes that degrade dopamine, epinephrine, and norepinephrine. COMT introduces a methyl group to catecholamines, donated by the nutrient S-adenosyl methionine (SAMe). Nutrients such as 5-methylfolate (bioactive B9) or methylcobalamin (bioactive B12) support the production of SAMe (Goodman JE, et al. Carcinogenesis. 2001). This is crucial for training performance as the accumulation of too much epinephrine or norepinephrine can lead to over-excitation ‘burn out’ from central nervous system (CNS) fatigue.

Vitamin B12 deficiency is associated with elevated levels of homocysteine (a proinflammatory molecule), fatigue, weakness and adrenal dysfunction (consequently leading to poor energy regulation and a lower androgenic profile).

The recommended minimum intake for B12 is 2.4mcg per day, this is easily hit from beef liver which supplies over 70mcg per 100g (now this may seem extremely high when compared to the RDA, due to it’s nature of being a water-soluble vitamin, toxicity levels are far higher, with no signs of oral toxicity from up to 2,000mcg).

Liver also has a considerable amount of folate (roughly 290mcg per 100g). In 100g of beef liver, there is just over 70% of the RDA requirements for folate (sitting around 400mcg) however this is roughly 3 times less than the optimal levels. We must note, folate is different to folic acid – folate is the bioavailable form that the body actually requires rather than the synthetic version, folic acid, which can place your body under greater amounts of stress dependent if you have a defect in the MTHFR gene. Folate is quintessential for proper methylation whilst also assisting with the recycling BH4 back from its used form, BH2 (Coppen A, et al. J Affect Disord. 1989). This is a key co-factor for the conversion of dopamine (amongst other neurotransmitters) and nitric oxide – thus increasing neural drive and performance whilst increasing the delivery of nutrient-rich, oxygenated blood to throughout the body.

Now I am going to talk about nucleotides, this is a classification of nutrients that are very powerful but unfortunately only known by a minority within the strength and performance world. You name it, Liver is incredibly abundant in this nutrient. They form the backbone of the DNA double helix – this is the most basic genetic material found in the nucleus of a cell that helps forms a blueprint of life. Nucleotides serve varied roles in energy metabolism (integral role of fat, protein and carbohydrates metabolism), enzymatic regulations, signal transduction and as structural components of coenzymes.

Dietary nucleotides are needed by certain cells and their functions for cellular regeneration, largely within the gastro-intestinal tract. Epithelial cells are situated within the intestines, their own production is too low to cover there needs for mucosa growth and its repair process (Sanderson IR, et al. J Nutr. 1994). Within the intestinal flora, specific strains are unable to produce their own nucleotides such as bifidobacterium longum (Rossi M, et al. Arch Microbiol. 2000). The health of the gut dictates your recovery capacity, and you can only train as hard as you can recover. This is done through mediating appropriate immune and inflammatory responses whilst optimizing nutrients digestion and assimilation required for new cellular turnover.

Another aspect how nucleotides can drastically support optimal recovery is the formation of lymphocyte and macrophage cells (Coffey RG, et al. Fed Proc. 1985). These cells are required for appropriate immune function and therefore your management of your biochemistry from training induced stress and inflammation. They have a fast proliferation rate which places a very high demand on nucleotide availability, therefore having a bigger pool of nucleotides means that they have a more efficient production rate.

Nucleotides support the oxygenation of blood, as erythrocyte cells are unable to produce their own nucleotides (Micheli V, et al. Quad Sclavo Diagn 1983). This will increase the circulation and flow of blood around the body to optimize performance and nourish muscles and organs with nutrients in order to heal.

Dietary nucleotides have indirect benefits to support other organs and metabolic processes such as liver function, repairing damaged DNA from oxidative stress and support RNA formation required for the formation of new proteins.

Nucleotides have also been shown to reduce post-exercise immunosuppression and hypothalamic-pituitary axis (HPA) axis activation, whilst also lowering cortisol and creatine kinase (J Strength Cond Res. 2016 Feb) therefore favouring a physiologically anabolic state.

Nutrition
6 min read
Top foods for improved training performance
Top foods for improved training performance
Part 1 of a five-part series exploring performance nutrition through a functional lens. This article examines how bone broth and liver support neural drive, joint health, recovery, and metabolic resilience to enhance strength and training performance.
September 10, 2025

The effectiveness of Vitamin B6 in the treatment of PMS dates back over 40 years. Results were noted, such as:

  • ‘Significant decreases in all symptoms’ (1)
  • 70% reporting good or partial response’ (2)
  • ‘Improvement in 63% of patients on pyridoxine’ (3)

The dose used within these studies ranged from 40-200mg (with a possible risk of toxicity at 200mg).

Only one patient of the 940 participating in these trials indicated the presence of any side effects that could be attributed to the neuropathy associated with pyridoxine toxicity. (4)

A meta-analysis of nine published trials involving almost 1,000 women with PMS found that vitamin B6 is more effective in reducing PMS symptoms than placebo. (5)

A double-blind, randomized controlled trial in 94 women found that 80 mg pyridoxine taken daily over the course of three cycles was associated with statistically significant reductions in a broad range of PMS symptoms, including:

  • Moodiness
  • Irritability
  • Forgetfulness
  • Bloating
  • Anxiety (6)

Below are my preferred dietary sources of Vitamin B6 per 100g:

  • Liver – 1mg
  • Salmon – 0.9mg
  • Sunflower Seeds – 1.33mg
  • Pistachios – 1.7mg

The recommended daily allowance sits around 1.3mg, which makes an easy target to obtain via food.

However, to achieve the dosage used in the above studies is between 30-153 times higher than the RDA, making it unachievable to obtain through diet alone.

As you can see here, Designs For Health provides 50mg of Vitamin B6 in just one capsule. This is in the form of Vitamin B6 in its most bioavailable form – P5P.

Magnesium and Vitamin B2 are required for the conversion of P5P. The deficiency rates of magnesium make this conversion much harder.

High protein diets or genetic susceptibilities (such as NBPF3) are factors that can increase the need for more Vitamin B6.

Have you ever used B6 for your PMS?

References:

  1. Goei and Abraham, 1983
  2. Brush, 1988
  3. Day, 1979
  4. London RS, et al. 1991
  5. Wyatt KM, et al. BMJ 1999
  6. Kashanian M, et al. 2007
Nutrition
6 min read
Vitamin B6 and PMS
Vitamin B6 and PMS
While food sources can meet daily requirements, the doses shown to improve PMS are difficult to reach through diet alone. Supplemental B6, particularly in its bioactive form (P5P), alongside adequate magnesium and vitamin B2, may support symptom reduction in susceptible individuals.
December 10, 2022
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