Gut Health
4 min read
December 10, 2022
H Pylori: 50% globally infected

H Pylori: 50% globally infected

Helicobacter pylori is a highly prevalent gram-negative bacterium that colonises the gastrointestinal tract, including the oral cavity. While often asymptomatic, it is a major driver of chronic gastritis, peptic ulcer disease, impaired nutrient absorption, and increased gastric cancer risk, with wide-ranging systemic effects.

Globally, more than 50% of all people are infected [8], with the prevalence of escalating with age. [9]

Helicobacter Pylori is a gram-negative bacterium that colonises within the human gastrointestinal tract (this includes the mouth).

Symptoms:

  • Belching
  • Nausea
  • Vomiting
  • Difficulty swallowing
  • Abdominal discomfort
  • Upper abdominal bloating
  • Decreased appetite
  • Peptic ulcers
  • Bad breath
  • Heartburn
  • Reoccurring oral plaque
  • Gingivitis
  • Tooth cavities

Risks:

  • H. Pylori infection is the main cause of chronic gastritis, with an infection rate between 80%-95% in sufferers. [7]
  • It is present in almost all cases of duodenal ulcers and most cases of gastric ulcer [10] with as many as 90% of individuals with ulcers being infected.
  • H. Pylori is a significant contributing factor for the risk of gastric cancers.
  • H. Pylori burrows deep within parietal cells (cells that secrete stomach acid), not only does this make it harder to eradicate, but this also leads to unique symptoms within the host. One factor being hypochlorhydria (low levels of stomach acid secreted within the body); this prevents the host from sterilising bacteria in food, reduces the ability to obtain nutrients desired from food and the inability to assimilate certain key minerals, such as zinc or iron.
  • Reduced intrinsic factor (IF) production is also likely for individuals suffering from a H. Pylori infection. IF is essential to bind with vitamin B12, preventing further breakdown from stomach acid along with attaching to the surface of the ileum to allow for absorption of B12 into the body.
  • H. Pylori can also block vitamin C absorption, thus compounding to the amount of oxidative damage inflicted onto the body.
  • H. Pylori infection augments the gastric mucosal damage induced by NSAIDs.
  • H. Pylori antagonises Aspirin-induced delayed ulcer healing due to suppression of acid secretion by the enhancement of PGE2 possibly derived by COX2 expression.
  • Benefits:
    Due to the nature of the parasite being a gram-negative bacteria, it shifts the immune system more towards a Th1 mediated response as opposed to Th2 – this can reduce the severity of allergies, asthma and other humeral/mucosal reactions.

Benefits:

Due to the nature of the parasite being a gram-negative bacteria, it shifts the immune system more towards a Th1 mediated response as opposed to Th2 – this can reduce the severity of allergies, asthma and other humeral/mucosal reactions.

References:

  1. Morales-Espinosa R, et al., Oral Microbiol Immunol. 2009
  2. Nguyen AM, et al., Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995
  3. Miyabayashi H, et al., Helicobacter. 2000
  4. Gebara EC, et al., J Clin Periodontol. 2006
  5. Dye BA, et al., Am J Public Health. 2002
  6. Eskandari A, et al. Med Oral Patol Oral Cir Bucal.
  7. Abro AH, et al. J Ayub Med Coll Abbottabad. 2011
  8. Saudi J Gastroenterol. 2014
  9. J Gastrointestin Liver Dis. 2011
  10. J Gastroenterol Hepatol. 2011
  11. Surveillance of Helicobacter pylori antibiotic resistance in England and Wales; Public Health England, 2008
  12. Jernberg, C, et al. 2010

Next news

Have you suffered challenges to your mental health?

Depression has the third highest burden of all diseases in Australia (13%) [1] and also third globally [2].

Almost half (45%) Australians will experience a mental illness in their lifetime [3].

One in five, about 20%, Australians aged 16-85 experience a mental illness in any year:

  • 11.5% have one disorder and 8.5% have two or more disorders.
  • 14% of Australians suffer from anxiety disorders.
  • 6% depressive disorders [4].

The age with the highest prevalence of mental illness is between 18-24 years of age.

21.2% of adolescents between 15-19 years of age met the criteria for a probable serious mental illness [5].

Six Australians die from suicide every single day, with a further 30 people will attempt to take their own life [6].

Suicide is the leading cause of death for people Australians aged 25-44 and the second leading cause of death for young people aged 15-24 [7].

Australians are more likely to die by suicide than skin cancer.

Indigenous Australians experience double the rate of suicide when compared to non-indigenous Australians [8].

The LGBT community experiences four times the rate when compared with those identified as heterosexual [9].

In 2011, men accounted for 76% of deaths from suicide [10], yet an estimated 72% of males don’t seek help for mental disorders.

54% of sufferers with mental illness do not seek treatment [1], which is only compounded by the delay in treatment due to problems with detection, social stigma and accurate diagnosis.

Individuals with mental illness accessing treatment are half that of people seeking treatment with physical disorders [11].It’s time to raise awareness for mental health.

References

  1. Australian Institute of Health and Welfare. (2014). Australia’s Health 2014. AIHW: Canberra.
  2. World Health Organisation. (2008). The global burden of disease: 2004 update.
  3. Australian Bureau of Statistics. (2009). National Survey of Mental Health and Wellbeing: Summary of Results, 4326.0, 2007. ABS: Canberra.
  4. Kitchener, B.A. and Jorm, A.F. (2009). Youth Mental Health First Aid: A manual for adults assisting youth. ORYGEN Research Centre, Melbourne.
  5. Ivancic, L., Perrens, B., Fildes, J., Perry, Y. and Christensen, H. (2014). Youth Mental Health Report, June 2014. Mission Australia and Black Dog Institute, Sydney.
  6. The Australian Senate. (2010). The Hidden Toll: Suicide in Australia Report of the Senate Community Affairs References Committee. Commonwealth of Australia, Canberra.
  7. http://www.aihw.gov.au/deaths/causes-of- death
  8. Australian Bureau of Statistic. (2012). Australian Health Survey: First Results. ABS, Canberra.
  9. National Mental Health Commission. (2013). A Contributing Life, the 2013 National Report Card on Mental Health and Suicide Prevention. NMHC, Sydney.
  10. Department of Health and Ageing. (2013). National Mental Health Report 2013: tracking progress of mental health reform in Australia 1993 – 2011. Commonwealth of Australia, Canberra.
  11. Commonwealth of Australia. (2010). National Mental Health Report 2010. Canberra, Australia.
Mental Health
6 min read
Mental health: do you care?
Mental health: do you care?
Mental health conditions are common, serious, and often untreated. Reducing stigma, improving early intervention, and encouraging help-seeking are critical steps toward prevention, support, and saving lives.
December 10, 2022

Got plaque?

The conventional approach uses a process known as ‘Triple Therapy’ – this is the combination of two different antibiotics in-conjunction with a proton-pump inhibitor (which lowers HCL).

Not only does this have a low success rate, but it makes the host vulnerable to infection from other pathogens and parasites post-treatment. This is due to decreased stomach acid and a lessened ability to sterilise bacteria within food along with less competitive dominance within the gastrointestinal tract due to the eradication of the microbiota (pathogenic and beneficial species) within the gut, leaving available space to harbour unwanted bacteria.

H. Pylori is starting to develop resistance to antibiotics, making the conventional approach less and less effective – leading to the ‘thought’ process of adding more medication to the mix to overcome this resistance by using ‘Quadruple Therapy’.

The Health Protection Agency reports that the prevalence of H. Pylori antibiotic resistance varies within the UK depending on location, from 20-63% for metronidazole and 4.4-11% for clarithromycin. [11]

This is one factor explaining why as many as 20% of affected individuals have a reoccurring infection even after treatment.

Another factor for reinfection is the presence of H. Pylori in the oral cavity [1–3]; therefore, failure to eliminate H. Pylori from the mouth could lead to gastrointestinal reinfection.

Gingivitis and chronic periodontitis may be associated with H. Pylori infection and considered as a potential reservoir for bacteria. [4,5]

The plaque should be removed professionally, and oral hygiene procedures should be performed along with eradication strategies of H. Pylori [6] to increase the probability of success.

One could argue that an alternative approach yields much less risk to the host when compared with the iatrogenic complications and long-term hindrance from antibiotics (especially given that a single course of antibiotics can disturb the microbiome for unto 2-4 years post-treatment [12]).

The following has been found effective when addressing H. Pylori:

  • Bismuth subcitrate
  • Mastic gum
  • Goldenseal/Berberine
  • DGL Licorice wafers
  • Matula tea

The following foods have also been found beneficial:

  • Coconut oil
  • Manuka honey

All this has to be addressed with the appreciation of humans being a multi-dimensional and bi-directional organism.

Seeking advice from a trusted professional is always recommended when dealing with any health ailments.

References:

  1. Morales-Espinosa R, et al., Oral Microbiol Immunol. 2009
  2. Nguyen AM, et al., Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995
  3. Miyabayashi H, et al., Helicobacter. 2000
  4. Gebara EC, et al., J Clin Periodontol. 2006
  5. Dye BA, et al., Am J Public Health. 2002
  6. Eskandari A, et al. Med Oral Patol Oral Cir Bucal.
  7. Abro AH, et al. J Ayub Med Coll Abbottabad. 2011
  8. Saudi J Gastroenterol. 2014
  9. J Gastrointestin Liver Dis. 2011
  10. J Gastroenterol Hepatol. 2011
  11. Surveillance of Helicobacter pylori antibiotic resistance in England and Wales; Public Health England, 2008
  12. Jernberg, C, et al. 2010
Gut Health
6 min read
Pylori, plaque and protocols
Pylori, plaque and protocols
Reducing plaque, addressing oral health, and using targeted non-antibiotic strategies may improve eradication success while lowering long-term risks to the gut and immune system. A whole-body, professional-guided approach is essential.
December 10, 2022

What is the Lymphatic System?

The lymphatic system is becoming increasingly more talked about but is still, in my opinion, one of the least appreciated and under-utilised systems in the restoration of movement dysfunctions and chronic health complaints.

Everybody, including health practitioners and those in the fitness industry, could benefit from understanding and implementing lymphatic techniques. You can consider that a homeostatic balance of the internal environment can be a true measure of health.

Lymphatic techniques can, therefore, aid the body in moving towards more of an internal state of homeostasis.

How does the lymphatic system function?

The lymphatic system is, in essence, the sewage system of the body.

It has the incredible ability to trap nearly all soluble antigens, roughly 99%, with its role in waste removal. This is significantly important for the other body systems to not become overwhelmed and develop issues as well.

The lymphatic system contains the thymus, an endocrine organ which is responsible for the development of T-lymphocytes, immune cells that are involved in fighting infection through the process of cell-mediated immunity.

The spleen plays a key role in the lymphatic system as the largest lymphatic organ, having a vital role in a host of detox processes, such as:

  • Filtering blood
  • Removing old dead red blood cells
  • The maturation of lymphocytes and macrophages to aid in fighting infection

The splenic communication of the tenth cranial nerve, the Vagus nerve, is crucial in reducing inflammatory cytokine production.

The tonsils also form part of the structure of the lymphatic system. With the tonsils formed of lymphatic tissue, housing lymphocytes and macrophages, they protect the digestive system and lungs from pathogens entering through the nose or mouth.

There is also a deep association with the gastrointestinal system through gut associated lymphoid tissues (GALT) known as Peyers Patches, with the role of the gastrointestinal system intrinsically linked to the immune system. Estimates suggest that roughly 70-80% of immune function is beholden to gastrointestinal health.

This amazing system also comprises millions of lymphatic vessels which, if placed end to end in a continuous line, would circle the earth four times! Alongside these vessels there are over seven hundred lymph nodes within the body, with the most populated areas being the neck, skin and the intestines.

This mass of lymphatic vessels works in uniform direction towards the heart, with valves interspersed to prevent any backflow from occurring. This one-way system is aided by the structure of the vessels which allow fluids to flow in the direction of clearance, but with numerous valves preventing backflow. Allowing the system to be cleared, very much how a filtration device on a fish tank would work.

The ability to regulate fluid homeostasis is a key aspect of the lymphatic system. The body contains fifteen litres of lymphatic fluid, predominantly of water, and roughly 10% of proteins, hormones and waste products. Comparing this to the five litres of circulating blood that we have, the body wouldn’t contain three times more lymphatic fluid than blood if it wasn’t a critical component of our survival!

From the five litres of circulating blood, over the course of a day, three litres of plasma leaks out into the interstitial space.

If not appropriately removed through the lymphatic system this can lead to swelling outside of the cellular space due to the increased fluid concentration and alterations in pressure.

Without effective drainage this can create stagnation in the fluids;
Let’s go back to the fish tank analogy above, we know that stagnation of fluids is detrimental to the ecosystem, the same being the case for our health.

In a system with appropriately functioning lymphatics, this plasma is removed from the interstitial space into the lymphatics system and circulated upwards towards the subclavian vein. This is where it flows into the venous system, before returning to the liver, detoxifying and purifying the blood.

Taking a deeper look into the pathway of the lymphatic vessels will give an understanding into the application of treating the lymphatic system.

As a one way system drains into the venous system at the bilateral sites of the subclavian veins, all lymphatic vessels are required to flow in this direction. The right upper quadrant of the body drains through the right lymphatic duct and into the right subclavian vein, whilst the remainder of the body drains through the thoracic duct into the left subclavian vein.

The thoracic duct is responsible for the majority of lymphatic flow and also houses the largest lymph node, the cisterna chyli, which is a major site of drainage for the liver. It’s crucial to keep this node functioning well as between 25-50% of the returning lymphatic fluid through the thoracic duct is returned from the liver.

There is an important bidirectional relationship between the cisterna chyli and the liver, with an overburdened liver that can’t move or function optimally placing more load on the cisterna chyli. Having a lymphatic system that can’t drain well, especially at the cisterna chyli, increases the potential to create stagnation around the liver. A lymphatic vessel that is unable to drain will not be able to receive fresh supply creating this backlog.

A fairly recent discovery reveals that the lymphatic system also continues up into the central nervous system through the glymphatics, more commonly known as the glymphatic system.

The glymphatic system has the same role as the lymphatic system, however it is only situated in the brain. This helps to reduce inflammation and drive the removal of waste products which is essential for overall brain health. Additionally, the protective benefits of this system helps to distribute fuel sources and various other vital components around the brain.

Detox
6 min read
The lymphatic system
The lymphatic system
By clearing waste, regulating fluid movement, and supporting immune and neurological health, the lymphatic system plays a central role in resilience and recovery. Optimising lymphatic flow can be a powerful, underutilised tool in addressing chronic health issues and restoring balance within the body.
November 14, 2022
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