Women's Health
4 min read
December 10, 2022
The prevalence of PMS

The prevalence of PMS

Premenstrual Syndrome (PMS) is a multifactorial condition affecting both physical and psychological health, with symptoms driven by hormonal fluctuations, nutrient status, and metabolic function. While conventional treatment often relies on SSRIs, growing evidence points to hormone balance and nutritional support as key factors in both the development and management of PMS.

PMS is characterised by a collection of physical and emotional symptoms that occur in the day before menstruation.

(Awanish Kumar Pandey, et al. 2013) indicated that 100% of girls tested showed a prevalence of at least one symptom of PMS, with 42.5% showing more than five symptoms.

Some of the most common psychological symptoms ranged from:

  • Lethargy (83%)
  • Anger and hypersomnia (74%)
  • Anxiety (68.5%)
  • Feeling overwhelmed (62.5%)
  • Hopelessness (50%)
  • Difficulty in concentrating (33.5%)
  • Tearfulness (26.5%)
  • Insomnia (26%)

Some of the most common physical symptoms ranged from:

  • Joint or muscle pain (77.5%)
  • Headaches (67%)
  • Weight gain (58%)
  • Backache (57.5%)
  • Bloating (41%)
  • Breast tenderness (31%)
  • Acne (*16.5%)

*16.5% may seem low when compared with some of the other figures mentioned above, however, this still equates to 1/6 women suffering from acne every single month around their menstruation.

The conventional approach for addressing PMS uses SSRI’s, which numbs the individual along with increasing the likelihood of suicide ideation, risks post-SSRI-sexual-dysfunction and depletes melatonin.

This complex condition likely has multiple causes, with fluctuations in hormone levels and nutritional deficiencies playing key roles.

OESTROGEN

One of the possible reasons for PMS has been associated with the excess of oestrogen relative to progesterone.

High oestrogen has also been found to increase thyroid-binding-globulin, which will reduce the activity of the thyroid hormones, further leading to apathy and a lack of energy. Ensuring oestrogen’s efficient metabolism through the correct pathways and supporting elimination from the body is paramount.

In short, this requires a range of nutrients from cruciferous vegetables, flaxseed and possibly grapefruit (grapefruit does have the ability to inhibit CYP3A4 enzyme which will decrease the metabolism of medication. Therefore grapefruit should be avoided to prevent medical complications).

PROGESTERONE

Progesterone is also at its lowest during the time of PMS. Progesterone acts on GABA receptors in the brain to produce a calming effect along with supporting thyroid conversion, thus assisting with energy.

The consumption of Wild Yams supports progesterone.

MAGNESIUM

Magnesium deficiencies may be causing or aggravating symptoms of PMS. Magnesium is essential for nerve, muscle function and the ability for the muscles to relax, all of which can be affected in PMS. (Iran J Nurs Midwifery Res. 2010 Dec).

A decrease of 12.42% in serum magnesium levels have been found in the follicular phase when compared to the menstruation with magnesium levels elevating a further 7% in the luteal phase. These fluctuations portray the role of magnesium in accordance with menstruation. Magnesium can be obtained through the consumption of dark chocolate or almonds.

IRON

In a meta-analysis, eating an iron-rich diet was linked to a 31% lower risk of developing premenstrual syndrome (Am J Epidemiol. 2013 May). Iron will be depleted during menses, thus further depleting levels. Iron is essential for energy regulation, along with being an essential a cofactor for the enzyme tryptophan hydroxylase, which catalyses the conversion of tryptophan into 5-hydroxytryptophan, a precursor for serotonin (the neurotransmitter associated with mood and happiness).

Iron obtained from plants is likely to have reduced bioavailability within the body. It is often accompanied by phytic acid and oxolates, both of which bind with the iron to prevent absorption.

Another factor to take into account when seeking to optimise iron levels within the body is stomach acid (HCl). HCl is essential to break iron down from food for assimilation within the body.

One can complete the baking soda challenge test for indication of whether their HCl is low or not, by drinking 250ml of water mixed with 1/4tsp of baking soda first thing in the morning. If the individual belches after the 3-minute mark, this would correlate to low HCl and therefore a likelihood that the individual will have poor digestion and assimilation of iron within their body.

ZINC

Women have a 24%–29% lower risk of PMS when in the top 2 quintiles of zinc to copper ratios (Am J Clin Nutr. 1995). Zinc deficiency is associated with depression while copper up-regulates the CYP19A1 enzyme, which leads to aromatisation of androgens to oestrogen (estradiol) while enhancing estradiol binding affinity to the oestrogen receptors, which amplifies its action.

Below are my preferred dietary sources of zinc per 100g:

  • Oysters – 61mg
  • Beef – 11mg
  • Hemp Seeds – 10mg

Zinc is another micronutrient which requires HCl for its assimilation, therefore assessing HCl status could also correlate with the potential zinc status within the individual.

VITAMIN B6

The effectiveness of Vitamin B6 in the treatment of PMS dates back over 40 years. Results were noted such as ‘significant decreases in all symptoms’ (Goei and Abraham, 1983), ’70% reporting good or partial response’ (Brush, 1988) and an ‘improvement in 63% of patients on pyridoxine’ (Day, 1979). The dose used within these studies ranged from 40-200mg (with possible risk of toxicity at 200mg).

Only one patient of the 940 participating in these trials indicated the presence of any side effects that could be attributed to the neuropathy associated with pyridoxine toxicity (London RS, et al. 1991).

Obtaining this level of Vitamin B6 effectively through food will be extremely difficult as these dosages are 29-115 times that of the recommended daily allowance.

Below are my preferred dietary sources of Vitamin B6 per 100g:

  • Organic liver – 0.6mg
  • Pistachios – 1.7mg
  • Salmon – 0.9mg

Above is just an example of how proper nutrition can support and mitigate against PMS.

Next news

Got plaque?

The conventional approach uses a process known as ‘Triple Therapy’ – this is the combination of two different antibiotics in-conjunction with a proton-pump inhibitor (which lowers HCL).

Not only does this have a low success rate, but it makes the host vulnerable to infection from other pathogens and parasites post-treatment. This is due to decreased stomach acid and a lessened ability to sterilise bacteria within food along with less competitive dominance within the gastrointestinal tract due to the eradication of the microbiota (pathogenic and beneficial species) within the gut, leaving available space to harbour unwanted bacteria.

H. Pylori is starting to develop resistance to antibiotics, making the conventional approach less and less effective – leading to the ‘thought’ process of adding more medication to the mix to overcome this resistance by using ‘Quadruple Therapy’.

The Health Protection Agency reports that the prevalence of H. Pylori antibiotic resistance varies within the UK depending on location, from 20-63% for metronidazole and 4.4-11% for clarithromycin. [11]

This is one factor explaining why as many as 20% of affected individuals have a reoccurring infection even after treatment.

Another factor for reinfection is the presence of H. Pylori in the oral cavity [1–3]; therefore, failure to eliminate H. Pylori from the mouth could lead to gastrointestinal reinfection.

Gingivitis and chronic periodontitis may be associated with H. Pylori infection and considered as a potential reservoir for bacteria. [4,5]

The plaque should be removed professionally, and oral hygiene procedures should be performed along with eradication strategies of H. Pylori [6] to increase the probability of success.

One could argue that an alternative approach yields much less risk to the host when compared with the iatrogenic complications and long-term hindrance from antibiotics (especially given that a single course of antibiotics can disturb the microbiome for unto 2-4 years post-treatment [12]).

The following has been found effective when addressing H. Pylori:

  • Bismuth subcitrate
  • Mastic gum
  • Goldenseal/Berberine
  • DGL Licorice wafers
  • Matula tea

The following foods have also been found beneficial:

  • Coconut oil
  • Manuka honey

All this has to be addressed with the appreciation of humans being a multi-dimensional and bi-directional organism.

Seeking advice from a trusted professional is always recommended when dealing with any health ailments.

References:

  1. Morales-Espinosa R, et al., Oral Microbiol Immunol. 2009
  2. Nguyen AM, et al., Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995
  3. Miyabayashi H, et al., Helicobacter. 2000
  4. Gebara EC, et al., J Clin Periodontol. 2006
  5. Dye BA, et al., Am J Public Health. 2002
  6. Eskandari A, et al. Med Oral Patol Oral Cir Bucal.
  7. Abro AH, et al. J Ayub Med Coll Abbottabad. 2011
  8. Saudi J Gastroenterol. 2014
  9. J Gastrointestin Liver Dis. 2011
  10. J Gastroenterol Hepatol. 2011
  11. Surveillance of Helicobacter pylori antibiotic resistance in England and Wales; Public Health England, 2008
  12. Jernberg, C, et al. 2010
Gut Health
6 min read
Pylori, plaque and protocols
Pylori, plaque and protocols
Reducing plaque, addressing oral health, and using targeted non-antibiotic strategies may improve eradication success while lowering long-term risks to the gut and immune system. A whole-body, professional-guided approach is essential.
December 10, 2022

Nutrition is the language of our cells –it dictates how we look, feel, function and perform. It is drastically undervalued when compared the uncountable list of benefits proper nutrition can yield. For this reason, I have decided to write about my top choices of foods that support physiological or neurological changes to favour improved training performance. My initial thoughts were to create a ‘top 10 foods’ article but anyone who knows me, will understand that I really love getting into the nitty-gritty detail.

This will be a 5-part series ranging through meats, nuts, seeds all the way through to vegetables and fruits.

Focal Points

The primary focal point for strength performance is to increase neurological drive (supporting dopamine and acetylcholine production) whilst avoiding any suppression (which would be induced from any GABAergic or serotonergic actions). This will optimise drive, motivation, muscle contraction, muscular tone, focus and clarity whilst avoiding any inhabitation or relaxation.

Other key factors to look at when improving performance would be to ensure that there are optimal levels muscle carnosine levels to buffer PH and offset fatigue, support thyroid function, improve blood flow, support DNA formation, strengthening structural connective tissue and activating the correct pathways to supply the body with available energy stores.

For optimum strength performance, you preferably want to avoid carbohydrates pre-training to ensure there is no pump-induced fatigue and to minimise serotonin secretion – therefore fats and proteins are best choices.

This being said, everyone is individual and what will be highly beneficial for one person may not reap similar effects in another due to food intolerances, nutrient status, hormonal levels and genetic code.

Bone broth – do you even bone though?

This is classed as ‘natures multi mineral’. For thousands of years humans have consumed bones, with theories going as far back as Palaeolithic eras. Bone broths contain bio-available minerals (easily absorbed by the body) such as; calcium, magnesium, phosphorus, silicon, sulphur to chondroitin sulphate and glucosamine.

Cooking bones in a broth releases a combination of nutrients that support:

  • Healthy joint mobility and function
  • Collagen biosynthesis
  • Modulating appropriate immune and inflammatory responses
  • Improved gut health
  • Joint health is a key limiting factor on strength and performance. The neurological system will inhibit strength as a self-safety mechanism to protect the joints by preventing any further damage.

One of the most valuable components of bone broth is gelatin, this acts like a soft cushion between bones that helps them move without friction. Gelatin also provides us with building blocks that are needed to form and maintain strong bones; helping take pressure off aging joints and supporting heathy bone mineral density. Weight training can increase bone density, joint health and mobility but only when it is complemented with an appropriate nutrient regime to feed the specific prosperities to do so.

Another key nutrient in bone broth is collagen, this is found in everything from our joints, bones, ligaments and tendons all the way down to the cellular level. Collagen supports the function of chondrocytes, these are small cells found within the cartilage of joints. Chondrocytes produce mucopolysaccharides and the formation of new collagen that keep joints cushioned and lubricated. Research done by the Department of Nutrition and Sports Nutrition for Athletics at Penn State University found that when athletes supplemented with collagen over the course of 24 weeks, there was significant improvements in joint comfort and a decrease in factors that negatively impacted athletic performance. (Clark KL1, Sebastianelli W, Flechsenhar KR, Aukermann DF, Meza F, Millard RL, Deitch JR, Sherbondy PS, Albert A)

Another powerful nutrient that supports joint health and functionality in bone broth is hyaluronic acid; this acts as a “shock absorber” for joints. It holds water and forms a gel-like substance, lubricating and cushioning joints by surrounding tissues found around nerves (predominantly found in the synovial fluid between joints).

Bone broth is also loaded with glycine. This is classed as a ‘conditionally essential’ amino acid. It is used in the synthesis of haemoglobin, creatine, porphyrin, bile salts, glutathione and the nucleotides DNA and RNA. Glycine is involved in gluconeogenesis (the manufacture of glucose), it helps drive glucose into cells acting similar to the function of insulin. ‘When glycine was ingested with glucose, the plasma glucose area response was attenuated by > 50% compared with the response after the ingestion of glucose alone’ (Mary C Gannon, Jennifer A Nuttall, and Frank Q Nuttall). This means that the athlete with be able to have a slighter high carbohydrate intake to restore glycogen levels, support mTOR, mitigate cortisol and improve training performance.

Glycine also assists digestion by enhancing gastric acid secretion. Research found that only certain proteins stimulate gastric acid secretion, glycine being one (Wald A, Adibi SA.) – thus helping protein digestion and assimilation for enhanced recovery from workout to workout.

Bone broths help mediate appropriate immune and inflammatory responses due to the nature of healing the gut wall (due to nutrients such as proline, glutamine, arginine, gelatin and collagen). This will improve the gut walls integrity and prevent intestinal damage and permeability. If the gut wall becomes permeable, undigested food, toxins and pathogens can pass through the intestinal barrier and into the bloodstream, resulting in a hyper-vigilant immune and inflammatory response to address the ‘foreign invaders’. A healthy response is required for appropriate modulation of training-induced inflammation and endocrine function to enable efficient recovery and optimise super-compensation for growth and development.

Last but certainly not least; roughly 66% of neurotransmitter (chemical brain messengers dictating functions throughout the body) production is made within the gut. If there is any distress or down-regulation in the gut, neurotransmitter production will decrease – resulting in a decrease neural drive.

If the gut wall is inflamed, there is high chance that the brains barrier (blood-brain-barrier) will also be inflamed due to inflammatory stimulation from the vagus nerve, a nerve connecting the gut directly to the brain. This will decrease the brains performance and neurotransmitter reception in the brain.

Go hard or go bone.

Learning to love liver

Organs meats are incredibly abundant in B vitamins, these are essential in detoxification, the citric acid cycle (energy production), neurotransmitter conversions amongst many other key functions within the body crucial for training performance and recovery.

Catechol-O-Methyltransferase (COMT) is one of several enzymes that degrade dopamine, epinephrine, and norepinephrine. COMT introduces a methyl group to catecholamines, donated by the nutrient S-adenosyl methionine (SAMe). Nutrients such as 5-methylfolate (bioactive B9) or methylcobalamin (bioactive B12) support the production of SAMe (Goodman JE, et al. Carcinogenesis. 2001). This is crucial for training performance as the accumulation of too much epinephrine or norepinephrine can lead to over-excitation ‘burn out’ from central nervous system (CNS) fatigue.

Vitamin B12 deficiency is associated with elevated levels of homocysteine (a proinflammatory molecule), fatigue, weakness and adrenal dysfunction (consequently leading to poor energy regulation and a lower androgenic profile).

The recommended minimum intake for B12 is 2.4mcg per day, this is easily hit from beef liver which supplies over 70mcg per 100g (now this may seem extremely high when compared to the RDA, due to it’s nature of being a water-soluble vitamin, toxicity levels are far higher, with no signs of oral toxicity from up to 2,000mcg).

Liver also has a considerable amount of folate (roughly 290mcg per 100g). In 100g of beef liver, there is just over 70% of the RDA requirements for folate (sitting around 400mcg) however this is roughly 3 times less than the optimal levels. We must note, folate is different to folic acid – folate is the bioavailable form that the body actually requires rather than the synthetic version, folic acid, which can place your body under greater amounts of stress dependent if you have a defect in the MTHFR gene. Folate is quintessential for proper methylation whilst also assisting with the recycling BH4 back from its used form, BH2 (Coppen A, et al. J Affect Disord. 1989). This is a key co-factor for the conversion of dopamine (amongst other neurotransmitters) and nitric oxide – thus increasing neural drive and performance whilst increasing the delivery of nutrient-rich, oxygenated blood to throughout the body.

Now I am going to talk about nucleotides, this is a classification of nutrients that are very powerful but unfortunately only known by a minority within the strength and performance world. You name it, Liver is incredibly abundant in this nutrient. They form the backbone of the DNA double helix – this is the most basic genetic material found in the nucleus of a cell that helps forms a blueprint of life. Nucleotides serve varied roles in energy metabolism (integral role of fat, protein and carbohydrates metabolism), enzymatic regulations, signal transduction and as structural components of coenzymes.

Dietary nucleotides are needed by certain cells and their functions for cellular regeneration, largely within the gastro-intestinal tract. Epithelial cells are situated within the intestines, their own production is too low to cover there needs for mucosa growth and its repair process (Sanderson IR, et al. J Nutr. 1994). Within the intestinal flora, specific strains are unable to produce their own nucleotides such as bifidobacterium longum (Rossi M, et al. Arch Microbiol. 2000). The health of the gut dictates your recovery capacity, and you can only train as hard as you can recover. This is done through mediating appropriate immune and inflammatory responses whilst optimizing nutrients digestion and assimilation required for new cellular turnover.

Another aspect how nucleotides can drastically support optimal recovery is the formation of lymphocyte and macrophage cells (Coffey RG, et al. Fed Proc. 1985). These cells are required for appropriate immune function and therefore your management of your biochemistry from training induced stress and inflammation. They have a fast proliferation rate which places a very high demand on nucleotide availability, therefore having a bigger pool of nucleotides means that they have a more efficient production rate.

Nucleotides support the oxygenation of blood, as erythrocyte cells are unable to produce their own nucleotides (Micheli V, et al. Quad Sclavo Diagn 1983). This will increase the circulation and flow of blood around the body to optimize performance and nourish muscles and organs with nutrients in order to heal.

Dietary nucleotides have indirect benefits to support other organs and metabolic processes such as liver function, repairing damaged DNA from oxidative stress and support RNA formation required for the formation of new proteins.

Nucleotides have also been shown to reduce post-exercise immunosuppression and hypothalamic-pituitary axis (HPA) axis activation, whilst also lowering cortisol and creatine kinase (J Strength Cond Res. 2016 Feb) therefore favouring a physiologically anabolic state.

Nutrition
6 min read
Top foods for improved training performance
Top foods for improved training performance
Part 1 of a five-part series exploring performance nutrition through a functional lens. This article examines how bone broth and liver support neural drive, joint health, recovery, and metabolic resilience to enhance strength and training performance.
September 10, 2025

Depression is a complex disease with multiple contributing factors. The diagnostic criteria for depression include:

  • Depressed or irritable mood
  • Decreased interest in pleasurable activities and ability to experience pleasure
  • Significant weight gain or loss (>5% change in a month)
  • Insomnia or hypersomnia
  • Psychomotor agitation or retardation
  • Fatigue or loss of energy
  • Feelings of worthlessness or excessive guilt
  • Diminished ability to think or concentrate
  • Recurrent thoughts of death or suicide
    (Berton O, et al. Nat Rev Neurosci. 2006)

Chances are that you have felt several of the above criteria but yet you may not have associated it with depression.

This is because depression is a broad term that may affect one person differently to the next, along with having a diverse range of possible causations.

Below is a list of some of the factors that can lead to depression and apathy:

  • Trauma
  • PTSD
  • Abuse
  • Post-natal depression
  • Adverse childhood exposure
  • Lack of safety
  • Economic struggles
  • Autoimmunity
  • Social isolation
  • Heartbreak
  • Social media
  • Lack of purpose
  • S.A.D – Seasonal Affective Disorder (Vitamin D deficiency)
  • Mold exposure
  • Anaemia
  • Sex hormone imbalances (Low/high oestrogen, low testosterone)
  • Hypo/hyper thyroidism
  • Stress
  • Pain
  • Chronic illness
  • Genetic traits
  • Methylation issues
  • Heavy metal toxicity
  • Parasites
  • Nutrient deficiencies (B6, etc)
  • Nutrient excess
  • Artificial light exposure
  • Poor sleep
  • Mitochondrial dysfunctions
  • Poor gut health
  • Gut/brain axis inflammation
  • Cytokine model of depression
  • Medication
  • Loss of a loved one
  • Divorce
  • Substance abuse
  • Neurotransmitter imbalances
  • Lyme
  • Toxic and ambivalent relationships

Each reason, being so unique, may require a completely different approach for therapy from the next.

This reverberates a quote of William Osler, stating ‘It is much more important to know what sort of a patient has a disease than what sort of a disease a patient has’. Unfortunately, society generally neglects the beauty of individuality whilst overlooking the crucial interplay and synergy from the multifactorial systems essential for optimal function within our body.

Mental Health
6 min read
The diversity of depression
The diversity of depression
Depression can arise from trauma, physiology, lifestyle, environment, or biochemical imbalance. Because no two cases are the same, effective care depends on understanding the individual—not just the diagnosis.
December 10, 2022
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